Do not take 5-HTP if you're taking other medications that increase serotonin levels, such as antidepressants like SSRIs and MAO inhibitors. Use caution when taking carbidopa, a medication for Parkinson's disease. 5-HTP is not recommended for people with Down syndrome, as it has been linked to seizures. Read more
5-HTP may interact with any drug that increases serotonin, including: antidepressants. migraine medications. pain medications.
Its levels begin to rise in the evening to promote sleep and fall in the morning to help wake you up. Therefore, supplementing with 5-HTP may promote sleep by increasing melatonin production in your body.
Early research shows that taking 25-150 mg of 5-HTP by mouth daily along with carbidopa seems to reduce anxiety symptoms in people with anxiety disorders. However, other early research shows that taking higher doses of 5-HTP, 225 mg daily or more, seems to make anxiety worse.
Administration of 5-HTP alone depletes catecholamines (dopamine, norepinephrine, and epinephrine). When dopamine depletion is great enough, 5-HTP will no longer function.
Too much 5-HTP in your body can cause a spike in serotonin levels, resulting in side effects such as: anxiety. shivering. serious heart problems.
When taken by mouth: It is possibly safe to take 5-HTP in doses of up to 400 mg daily for up to one year. The most common side effects include heartburn, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems, and muscle problems. Large doses of 5-HTP, such as 6-10 grams daily, are possibly unsafe.
Because your body sees increased amounts of 5-HTP as a signal to synthesize serotonin, if you take 5-HTP for sleep 30 minutes before bed time, it should "start working" immediately.
Safety and Side Effects
1 The most common side effects reported with 5-HTP include nausea, vomiting, and diarrhea. Less common side effects include a headache, insomnia, and heart palpitations.
Gradually increasing a bedtime dose of 5-HTP from 50 milligrams to 200 to 300 milligrams over a period of two to three weeks often improves the quality of sleep in chronically anxious patients who complain of insomnia while also reducing the severity of daytime anxiety.
Some natural medicine proponents believe that taking 5-HTP supplements can help reduce anxiety and panic. However, most of the research about 5-HTP and anxiety is 15–20 years old. One research study from 2002 found that taking 5-HTP reduced anxiety and panic in people with panic disorder.
Try 5-HTP. Serotonin has been called the body's natural mood stabilizer. When serotonin levels are out of balance, people can suffer from low energy and “feeling blue.” 5-HTP can help. In fact, some studies have shown that 5-HTP supplementation can be just as effective in some people as traditional antidepressants.
Interactions between your drugs
No interactions were found between 5-HTP and melatonin. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
The side effects of 5-HTP include: agitation, drowsiness, flushing, headache, mild stomach upset, and tachycardia (fast heart rate). There is a small risk of developing liver toxicity when using 5-HTP.
No significant side effects of treatment were observed. The reduction of blood pressure accompanying treatment with L-5-hydroxytryptophan suggests that at least a portion of the antihypertensive effect of L-tryptophan is mediated via serotonin.
The biological half-life of 5-HTP ranged from 2.2 to 7.4 hours, and the plasma clearance ranged from 0.10 to 0.23 1/kg/hour.
The best supplements for anxiety are thought to be GABA, passionflower, valerian root, licorice root, ashwagandha and rhodiola. Omega-3 fatty acids, probiotics, B vitamins and L-theanine are natural vitamins for anxiety. Always check with your doctor before adding new vitamins to your diet.
Dietary supplements containing 5-HTP are claimed to help promote feelings of happiness and general well-being as well as a wide range of other positives such as appetite control, reduced anxiety, and improved mood, sleep and feelings of relaxation.
5-HTP works in the brain and central nervous system by increasing the production of the chemical serotonin. Serotonin can affect sleep, appetite, temperature, sexual behavior, and pain sensation. Since 5-HTP increases serotonin levels, it is used for conditions in which serotonin is believed to play an important role.
Interactions between your drugs
No interactions were found between 5-HTP and ashwaganda. This does not necessarily mean no interactions exist.
Melatonin seems to work best when people have low melatonin levels, not if their levels are normal. It is useful for jet lag, ADHD, insomnia. 5-HTP comes from L-tryptophan and increases seratonin production and seratonin increases melatonin production in turn.
5-HTP might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking 5-HTP along with sedative medications might cause too much sleepiness.
Taking 5-HTP with Demerol may cause serotonin levels to increase to dangerous levels, a condition called serotonin syndrome.
People who are taking antidepressant medications should not take 5-HTP without their provider's supervision. These medications could combine with 5-HTP to cause serotonin syndrome, a dangerous condition involving mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma.
Research suggests that taking magnesium for anxiety can work well. Studies have found that feelings of fear and panic can be significantly reduced with greater magnesium intake, and the good news is that the results aren't limited to generalized anxiety disorder.